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Graphical Abstract Similar content being viewed by others Introduction Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of the metabolic syndrome, which is believed to affect approximately 25% of adults worldwide and more than half of individuals with type 2 diabetes mellitus [1]

Most research has focused on fat metabolism, while separate animal studies have also looked at joints and cartilage

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PMID: 2706459

Before their cellular effects can be fully explained, more thorough studies are required to fully understand the signaling pathways affected by dual- and triagonism