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Beyond adipose tissue, GPR81 is abundantly expressed in skeletal muscle, kidney, brain, heart and various cancer types (8)
Food and Drug Administration (FDA) has explicitly approved Wegovy for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) who have at least one weight-related condition (like high blood pressure)
some early weight change can appear
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The dose is increased in steps (1.5 mg, then 4 mg, 9 mg and 25 mg), with a minimum of one month at each level, to help reduce side effects
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