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These are typified by the following two enzymes: Methylmalonyl-CoA mutase [edit] Methylmalonyl coenzyme A mutase (MUT) is an isomerase enzyme that uses the AdoB 12 form and reaction type 1 to convert L-methylmalonyl-CoA to succinyl-CoA, an important step in the catabolic breakdown of some amino acids into succinyl-CoA, which then enters energy production via the citric acid cycle
Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application
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Enzymatic activity differs
There are practical reasons too: B can be unstable if mixed with certain other vitamins in solution, and dosing schedules for B deficiency (pernicious anemia, for instance) may differ
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