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Previously reported RNA sequencing (RNA-seq) data 25 revealed a significant upregulation of astrogliosis markers, including glial fibrillary acidic protein (GFAP), monoamine oxidase B (MAOB), 18 aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1), acetaldehyde dehydrogenase 2 (ALDH2), and aquaporin 4 (AQP4) 19,26 (Supplementary Fig