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As for the difference between our study and the previous understanding, it might be due to the fact that the weight loss strategy we focused on was AOMs, and there was no restriction on the degree of weight loss and weight regain when included

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12 , 15 , 16 The composite gastrointestinal events and nausea occurred more frequently with semaglutide 2.4 mg and tirzepatide 15 mg compared to placebo (proportion of all gastrointestinal events and nausea, 63.5% and 33.7%, respectively, for semaglutide 2.4 mg vs

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