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Glutathione is a substance in the body made from three amino acids, namely, glycine, cysteine, and glutamic acid
2 AURA (2017)
For example, studies using rodents and primary neuron cultures have demonstrated that sulforaphane upregulates key antioxidant enzymes, such as glutathione-S-transferase (GST), NAD(P)H oxidoreductase 1 (NQO1), and heme oxygenase-1 (HO-1), leading to reduced oxidative burden in both neurodevelopmental and neurodegenerative models (Vauzour et al., 2010
We therefore sought a strategy to reduce the scale of the library to remain within the quantitative throughput limits of our assay (up to ~40,000 substrates), while still assaying a full repertoire of sequences likely to be cleaved by our evolved proteases (Extended Data Fig
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The review also documented GSHs role in regenerating vitamin E following detoxification of lipid peroxyl radicals, its involvement in the glyoxalase systems detoxification of dicarbonyl stress induced by methylglyoxal and glyoxal, and its regulation of redox signalling through reversible S-glutathionylation of critical protein cysteine residues
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