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No study involving older adults, including diabetic men, postmenopausal women, or patients recovering from orthopedic or cardiac surgery, reported supplementation-related adverse events (Nishizaki et al., 2015

418 Rechallenge strategies, by contrast, operate under the premise of clonal evolution reversibility, whereby reintroducing previously used agents, often after a drug holiday, can resensitize tumors due to regrowth of drug-sensitive clones

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Enforcement discretion is the most realistic near-term development

Patience matters here