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In addition to the newer GLP-1 drugs on the market, the study evaluated clinical trials on various weight-loss drugs, including older-generation GLP-1 medications and those outside of the class, such as orlistat and the combination of phentermine and topiramate
LDN is titrated to minimize side effects like vivid dreams which typically present in the early stages of drug initiation
Overall, although the overall absolute risk increase is small (27 cases per 10,000 persons treated per year), clinical practitioners should nevertheless take into account the potential risk of gallbladder or biliary diseases associated with GLP-1RAs, especially when used at higher doses, for longer durations, and for weight loss, and in case the patient has a history of lithiasis [64]
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Choosing the right GLP-1 program requires evaluating three dimensions: medication formulation and dosing flexibility, provider support and clinical monitoring, and access to biomarker or genetic context that personalizes treatment decisions
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