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In comparative receptor binding studies, Melanotan II demonstrates 5-10 fold higher potency at MC1R than PT-141, which directly correlates with Melanotan II's stronger melanogenic effects in melanocyte culture models
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Figure 6 shows that the hydrophobic sidechains of Ile1 and Ile 3 of Diprotin A are in close proximity, and this hydrophobic interaction may stabilize the peptide in an conformation that is not suitable for reaction progression
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