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Iron is absorbed into intestinal cells through DMT1 ( 2+ , or oxidized by FPN1 and combined with transferrin to enter the bloodstream ( The results of this study indicated that compared with non-pregnant rats, the expression of hepatic HAMP mRNA in physiological pregnant rats significantly decreased, while the expressions of small intestinal FPN1 and DMT1 + IRE mRNA significantly increased, and the serum level of TF also showed a significant increase

Berberine is a plant alkaloid that activates AMPK pathways affecting glucose and lipid metabolism