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This activation facilitates the synthesis and secretion of various inflammatory factors by epidermal and dermal cells, including interleukin-1 (IL-1), interleukin-6 (IL-6), cyclooxygenase-2, and tumor necrosis factor-alpha (TNF-), which collectively induce inflammatory responses (85, 86)

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Nuclear factor kappa-light-chain-enhancer of activated B cells, mercifully shortened to NF-kB, is a transcription factor that regulates the expression of hundreds of genes involved in inflammation, immune response, and cell survival

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