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Similarly, elevated global DNA methylation, Dnmt activity, and 5-methylcytosine but decreased Tet activity and 5-hydroxymethylcytosine were observed in the GSH-deficient hepatocytes and the liver of HFD-fed mice
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f ) Percentage of GR signal in the nucleus by treatment condition
Adenosylcobalamin excels for energy support
GSH depletion triggered by the Nrf2/ATF3/4/ChaC1 pathway appears to be the primary factor inducing death in drug-resistant tumor cells (138), positioning ChaC1 as a key target for certain potential anti-tumor drugs such as busatol (139) and glaucocalyxin A (140)
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