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We explore the early discoveries behind incretin hormones, the development of GLP-1based therapies, and their expanding role in diabetes, obesity, and cardiovascular care
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The peptides discussed are not approved for human consumption, clinical diagnosis, treatment, or any form of in-vivo use outside of controlled research settings
These in vitro results have been further validated in murine models of malaria infection and rheumatoid arthritis, where G6PD-d or inhibition leads to less severe proinflammatory responses to stimulation marked by reduced Th1 and Th17 differentiation, decreased proatherogenic cytokines IL-1, IL-6, IL-12, and TNF, and no impact on IL-10 and TGF (classically Treg-derived) 120,121,122,123,124