Introduction The human body is a remarkable system that constantly strives for balance, known as homeostasis
In vascular dementia (VD), chronic cerebral ischemia drives ferroptosis through dual mechanismsiron metabolism imbalance (upregulation of transferrin and its receptor TfR1 and downregulation of iron export protein FPN) results in the buildup of free iron within neurons, while oxidative stress accelerates lipid peroxidation by inhibiting GPX4 synthesis and upregulating ACSL4
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Meanwhile, aberrantly activated PI3K signaling upregulates ER expression via sustained activation of the PI3K/AKT/mTOR pathway, forming a resistance-promoting feedback loop