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The earliest plausible FDA approval is 2027
Studies using single oral doses of metformin HCl tablets 500 mg to 1,500 mg, and 850 mg to 2,550 mg, indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption rather than an alteration in elimination
Most stability loss occurs during the first temperature excursion, not through gradual decay over the stated storage period
The investigators searched the literature and located 304 randomized, placebo-controlled trials with information on GI side effects on 15 antidepressants (including SSRIs, SNRIs, bupropion, and mirtazapine)
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