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If the pinch test produces less than half an inch of tissue at your usual spot, consider transitioning to a site with more subcutaneous depth

However, rare cases of acute kidney injury have been reported, primarily linked to severe dehydration from GI side effects

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Chronically elevated cortisol promotes central obesity by stimulating fat accumulation in visceral depots while causing muscle wasting in the extremities

The article frames beyond-use dating as the output of that testing, which is why it differs from pharmacy to pharmacy and from formulation to formulation rather than being a single industry-wide number