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In addition to the impact of diabetes-related complications on quality of life, the impact of changes in weight was captured by applying a disutility of 0.0061 per BMI unit above 25 kg/m
The main goal is to bypass the gut
The most promising interventions should be those capable of converting subpopulations of neurotoxic astrocytes into an anti-inflammatory and neuroprotective state, rather than simply inhibiting their disease-associated profile
Aim for 0.8-1.2 grams per kilogram of body weight daily, with a minimum of 60 grams per day regardless of body weight
Pre-care instructions: Drink more water
Discontinuation rates for tirzepatide in the 72 week SURMOUNT-1 trial were 4.3%, 7.1% and 6.2% for the three doses and 2.6% for the placebo group
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