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Semaglutide (the active ingredient in Wegovy and Ozempic) functions through a completely different pathwayit mimics glucagon-like peptide-1, a hormone your gut naturally produces after eating
Hershman of Columbia University in New York, so this is not like a lot of studies where you find a statistically significant difference thats not clinically meaningful. In addition, the incidence of grade 3/4 neurotoxicity was 3.8% with ALC, much higher than the 0.5% seen with placebo
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Mild side effects, such as stomach discomfort and nausea, may happen to some people
scramble: 38.3% 5.9%, n = 9
Around the same time, I think you remember that all of pharma was interested in obesity in the early 90s, everyone wanted to do diabetes as well as obesity, but they were separate teams and they all wanted to do small molecules, but it just happens to be so that the best idea we could find at that time was actually GLP-1, because we actually had clinical data relatively early that GLP-1 was a really good candidate as a treatment for diabetes because of the glucose sensitivity of the actions
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