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Though there has been some rudimentary research work indicating that the GLP-1 receptor agonists can indirectly provide mood-enhancing effects by regulating the dopamine reward system, lessening inflammatory responses, or improving metabolic status, adverse events that have been observed in real life studies and case reports can suggest that their action at the central nervous system is more complicated [11, 16, 17]

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Phase 3 trials are still generating the data that regulators will need before any approval decision

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This observation led to the hypothesis that AngIV and AngIV analogs may be interacting with the HGF/Met system