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For example, liraglutide has been shown to decrease levels of tumor necrosis factor-alfa (TNF-alfa)-induced secretion of intracellular adhesion molecule, VCAM and PAI-1 from human umbilical vein endothelial cells (248)
GLP-1 receptor agonists slow stomach emptying, which may reduce absorption of oral medications in some people
In the placebo arm, just 0.7% of patients reported this side effect
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![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)