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Description

Then literatures reported the Ala177Val mutation has no influence on the kinetic parameters of bacterial MTHFR, but rather reduces enzyme stability and affinity for cofactor, and thus increases the tendency to form inactive enzyme via flavin dissociation, compared to the wild-type enzyme 27

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doi: 10.1016/j.tifs.2021.02.066 54 AmareshYSKavyasriMAshwathanarayanaDSRaghavendraBTHiregoudarS

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