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It doesnt exclude a whole lot of patients, remembering that the prevalence of medullary thyroid cancer and MEN 2 in the general adult population is somewhere between 1 in 30,000 and 1 in 40,000. Pearce adds that patients and doctors alike should not be unduly concerned by any possible effects on the thyroid

ArthritisA separate Phase 3 trial, TRIUMPH-4, paired weight loss with knee osteoarthritis

Additional Phase III trials are ongoing to confirm these findings across broader populations

Individuals should plan weight management therapy around their reproductive goals, with appropriate timing of discontinuation before conception attempts

Those pregnant, breastfeeding, or undergoing cancer treatment should avoid it until more data becomes available