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Bilirubin is an endogenous compound that can be toxic under certain conditions but, on the other hand, mild unconjugated hyperbilirubinaemia might protect against cardiovascular diseases and tumour development

Similarly, the recent SEMALEAN study found that participants with a history of MBS exhibited greater weight loss and more pronounced reductions in body composition parameters (total fat mass) with semaglutide 2.4 mg compared with those without a history of MBS 28

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