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Contributing factors to age-related decline: Reduced GHRH secretion Increased somatostatin tone Decreased GHSR sensitivity Altered sleep architecture (less deep sleep) Increased adiposity (fat suppresses GH) Consequences of GH Decline The somatopause correlates with many aging-associated changes: Research Rationale for Secretagogues GH secretagogues are researched as potential approaches to age-related decline because they preserve natural regulation (working with, not against, physiological systems), avoid exogenous GH risks (receptor downregulation, supraphysiological levels), maintain pulsatility (preserve natural secretion patterns), and are potentially saferthough this remains to be proven in long-term studies

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