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The rubber stopper is crumbling Repeated needle punctures can degrade the rubber stopper, causing tiny pieces of rubber to break off into the solution
PubMed Kang, E.A., Han, Y.M., An, J.M., Park, Y.J., Sikiric, P., Kim, D.H., Kwon, K.A., Kim, Y.J., Yang, D., Tchah, H., & Hahm, K.B
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