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However, these trials concentrated on cardiovascular outcomes rather than ocular ones, with inconsistent definitions and grading, rendering them insufficient for evaluating the long-term stabilization or enhancement of retinal pathology following an acute reduction in glycosylated hemoglobin (HbA1c)

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For most patients, the GI effects are more manageable than cardiovascular stress, but individual tolerance varies

cDNA was synthesized using Superscript III First-Strand Synthesis System (Invitrogen, Carlsbad, CA) according to manufacturers instructions using 1 g total RNA in a 20 l reaction volume

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Regulation of survivin expression by IGF-1/mTOR signaling [PMID: 17072337] Laboratory literature summary: Regulation of survivin expression by IGF-1/mTOR signaling