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In healthy individuals, GLP-1 is released after food consumption, particularly in response to proteins and fats, signaling satiety and stimulating insulin secretion

After 6 months, those taking the semaglutide had average blood sugar reductions of 0.6% to 1.1%, with bodyweight reduction of around 5 pounds for the 14-mg dose

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If you find yourself in this situation, monitor glucose closely if diabetic, reduce sulfonylurea or insulin doses preemptively, and start retatrutide at 2 mg without escalation until 4 to 6 weeks have passed