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It does mean synergistic is currently a hypothesis borrowed from mechanism, not a finding derived from data and researchers designing studies around these materials should know which one theyre working with
Clinical Trial Outcomes with Monotherapy The REDEFINE 1 trial demonstrated that cagrilintide monotherapy at the 4.5 mg maintenance dose produced mean body weight reductions of approximately 10.8% from baseline after 32 weeks of treatment [4]
Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial
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Nature 414 , 412 (2001)
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