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10.1038/nature02553 Nature 149 Schmidt-SalzmannC.LiL.BischofbergerJ

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FOXO4-DRI has a rapidly expanding and high-impact published research base, with studies published across Nature, Nature Communications, Communications Biology, Aging, Frontiers in Bioengineering and Biotechnology, and PMC since its foundational description in 2017

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The NIH reports that only about 10 micrograms of a 500-microgram oral supplement are actually absorbed in healthy people due to limitations of stomach acid and intrinsic factor

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