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doi: 10.1093/cid/cis251
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The defining characteristic of methylcellulose is what it does not do
It points to B vitamins and magnesium as the deficiencies worth investigating when discomfort does not settle, alongside dehydration and pre-existing musculoskeletal conditions
Repeated, sustainable food changes that increase fermentable substrates in the colon and ensure regular protein at meals can change microbial fermentation patterns and modestly increase GLP-1 over weeks to months, leading to more consistent satiety for many people, though results vary by individual microbiome
