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From there, our professional team supports you every step of the way, from administering injections to offering advice on healthy habits
(2006), a Phase 2 study of 65 healthy adults showing dose-dependent IGF-1 increases roughly 1.5 to 3-fold above baseline
Many studies had small sample sizes or no long-term follow-up
hypoglycemia risk if on insulin) eGFR below 30 (tirzepatide exclusion in SURMOUNT-5) Recent cardiac event or NYHA Class IV heart failure Active suicidal ideation (trials excluded PHQ-9 scores of 15 or above) If your tirzepatide vs semaglutide question is pure weight loss without comorbidities, tirzepatide wins on the numbers
How to maximise weight loss on GLP-1 medications Here are key strategies to get the most from your GLP-1 therapy while protecting your long term health
January 2026 milestone: The FDA approved an oral formulation of Wegovy (semaglutide) for chronic weight management in December 2025 the first GLP-1 pill ever approved for obesity treatment
