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10.1002/jsfa.6936 14 BertschC.Ramirez-SueroM.Magnin-RobertM.LarignonP.ChongJ.Abou-MansourE.et al

Conformational changes that correspond to the binding of PrP with Cu 2+ are associated with prion disease, and these are usually induced by alterations to Cu 2+ -to-histidine occupancy within the PrP molecule

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Further, 12 of them have been recognized as putative drug transporters, including well-known P-gp encoded by the ABCB1 gene, MDR-associated protein 1 (MRP1, encoded by the ABCC1 gene), and ABC subfamily G member2, also known as breast cancer resistance protein, which is encoded by the ABCG2 gene [78, 79]

Editorial: role of Nrf2 in disease: novel molecular mechanisms and therapeutic approaches