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Patients with EPP have a deficiency in an enzyme, leading to a buildup of protoporphyrin IX, especially in the skin and blood

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danuglipron oral GLP-1 discontinued 2024 Key Peptide Products: Somavert (pegvisomant GH receptor antagonist), Genotropin (somatropin growth hormone peptide), BNT116/mRNA oncology vaccines, historical insulin franchise, Lupron (leuprolide US rights via Abbvie partnership) Therapeutic Segments: Oncology (Ibrance, Xtandi partnership, Padcev, Lorbrena)

Fetching molecular profile AHK-CuAlso known as: Alanine-Histidine-Lysine-Copper tripeptide, Copper tripeptide-1, Copper peptide GHK-Cu analogue Mechanism of Action AHK-Cu functions by binding copper ions which facilitates cellular communication and skin repair processes

PMID 28596247

The cGMP that is produced via NO activation of soluble guanylate cyclase (sGC) in this tissue is degraded by a specific cyclic nucleotide phosphodiesterase (PDE) identified as PDE5A