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Combining HRT with some other intervention, whether thats habits or habits plus GLP-1s, shows much better results in clinical studies.

DOI: 10.1097/01.NPR.0000000000000430,

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Discontinuation of treatment or switching between agents should be reserved for patients with persistent or severe symptoms despite optimised management strategies

In contrast, constipation can often be alleviated by increasing dietary fibre and fluid intake, with the possible use of stool softeners and encouragement of regular physical activity [15]

Retatrutide remains investigational and has not received regulatory approval for human use in Canada or elsewhere