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So why is the American Red Cross asking this question

For example, obesity is a risk factor for AD and disruption of insulin signalling in the brain leads to a higher risk of AD 29 , however ALS patients tend to be hypermetabolic and it has been shown that increasing glucose levels in models of ALS is protective 30

Step three: combination and intensification For patients who do not reach their targets on either medication alone, combining basal insulin with a GLP-1 agonist is an increasingly popular strategy

SGLT2 inhibitors were chosen as the comparator given they are guideline-recommended second-line glucose-lowering medication and share similar cardiovascular benefits with GLP-1RA, which helps reduce confounding by indication

While retatrutide is not yet available, there are already safe and effective options that can be prescribed today, including Mounjaro and Wegovy

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