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Pharmacokinetic and pharmacogenomic determinants represent an additional source of interindividual variability in susceptibility
Basic cleanliness rather than strict sterility suffices, though clean handling always preserves product quality better
After incubation on ice for 1 h, the homogenates were centrifuged at 20,400 g for 20 min at 4 C, and the resulting supernatants were appropriately diluted and used in the assays
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In silico molecular docking further supports this, showing that Epitalon has a high binding affinity for specific histone subtypes, H1/3 and H1/6, which play a regulatory role in chromatin compaction and accessibility [4]
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