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Association between Glucagon-Like Peptide-1 Receptor Agonists Use and Change in Alcohol Consumption: A Systematic Review. eClinicalMedicine , vol
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What the semaglutide evidence base shows Semaglutide for weight management was studied in the STEP program (published in The New England Journal of Medicine , 2021), with populations and endpoints that vary across trials and individual outcomes that vary too
Benchmarking against SUSTAIN-6 and SURPASS-CVOT In the emulation of SUSTAIN-6 comparing semaglutide to sitagliptin, a proxy for placebo, in patients at moderate and high cardiovascular risk (Table 2 and Supplementary Table 19), the hazard ratio (HR) for the primary endpoint was 0.68 (95% confidence interval (CI) 0.600.77) compared to the trial estimate of HR 0.74 (95% CI 0.58 to 0.95)
recommendations for their implementation are given by Simone et al
Identification of functional toxin/immunity genes linked to contact-dependent growth inhibition (CDI) and rearrangement hotspot (Rhs) systems
