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Visceral adiposity contributes to chronic low-grade inflammation through macrophage activation, altered T-cell responses, and adipokine imbalance ( Beyond obesity, insulin resistance and hyperinsulinemia appear to play an active role in sustaining inflammatory arthritis rather than representing mere epiphenomena of chronic inflammation
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Interestingly, UPR mt activation has been linked, for example, to drug-induced lifespan extension [63, 64]
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
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