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Presented for research literature review only Pettigrew NE et al
Once-daily dosing offers simplicity and better compliance, while split dosing theoretically maintains more stable tissue concentrations throughout the day
If you notice no benefit by week 4, continuing is unlikely to produce different results
Researchers should define the main question before selecting a model: whether the study is testing cytoprotection, migration, proliferation-associated endpoints, angiogenesis, extracellular matrix remodeling, endothelial signaling, or tissue-level recovery
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