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For instance, exenatide, the first GLP-1-analogue developed, demonstrated to promote human monocyte differentiation into alternatively activated M2 macrophages, leading to an increase in anti-inflammatory cytokines such as IL-10 while significantly reducing pro-inflammatory cytokines, including IL-6, TNF- and IL-1 ( Furthermore, GLP-1 has been hypothesised to act as a mediator between innate and adaptive immune responses
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Study on the hepatocellular carcinoma model with metastasis
Preclinical research has examined its behaviour in models relating to wound healing response, dermal fibroblast activity, hair follicle cycling, and antioxidant pathway regulation
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