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[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%

Althaher AR

Timing considerations Injection timing affects both efficacy and side effects

Other reported effects include: Headaches and dizziness Nausea and gastrointestinal discomfort Allergic reactions to B12 formulations (rare) If you experience symptoms suggesting a severe allergic reaction (difficulty breathing, severe rash, swelling of face/throat), seek emergency medical attention immediately by calling 999 or attending A&E

However, it isnt possible to know exactly how much B12 you are receiving this way

Timing determines whether that knock arrives when the system can register it clearly, or whether repeated administration blurs the response