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doi: 10.2147/JIR.S275595 6 Sharifi-RadMv.AKNZuccaPVaroniEMDiniLPanzariniEet al

Downregulation or deficiency of pyruvate kinase leads to ATP depletion which in turn affects cell viability as well as accumulation of the glycolytic intermediates (2,3-diphosphoglycerate (2,3-DPG) that eventually leads to impaired glycolytic flux 46

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