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Derivatives thereof A61K38/17Peptides having more than 20 amino acids
The recent discovery of the small molecule N6F11, which binds the tripartite region of Trim25 and promotes proteasome-degradation of GPX4 in pancreatic cancer cells, while sparing immune cells and the anti-tumoral response of the microenvironment, could represent a major clinical breakthrough for the use of GPX4 inhibitor/degrader [61]
16 Using the Ala 18 from GLP-1 may support GIP activity by chance
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