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Although the mechanisms leading to a blood pressure decrease during the treatment with GLP-1 agonists have not been fully elucidated it could be the result of an increased sodium and water excretion and/or inhibition of the RAAS activity 14

doi:10.1016/j.expneurol.2016.01.007 16

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Phentermine is a short-term medication that reduces appetite, while Semaglutide/GLP-1 for weight loss helps regulate appetite and blood sugar levels by acting on the same hormone as GLP-1