UPMC Medical Weight Management prescribes only GLP-1 medications approved by the Food and Drug Administration
I generally tell people that if theyre having mild nausea or constipation, see if youre able to ride it out, he says
Seek Urgent or Emergency Care Do not keep treating sulfur burps at home when they occur with: Severe or persistent abdominal pain, especially pain that radiates to the back Repeated vomiting, inability to keep liquids down, fainting, confusion, or very little urine Vomiting blood or material that looks like coffee grounds Black tarry stool, maroon stool, or visible blood A swollen or increasingly painful abdomen with inability to pass stool or gas Chest pressure, shortness of breath, severe weakness, or pain spreading to the arm, jaw, or back High fever, stiff abdomen, severe diarrhea, or rapidly worsening illness People using semaglutide, tirzepatide, or another GLP-1based medicine should take severe abdominal pain, persistent vomiting, major abdominal swelling, inability to hydrate, or inability to pass stool or gas seriously
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But the GLP-1 boom has created an opportunity for compounders that has transformed pockets of the industry, with compounding pharmacies producing off-brand duplicates for likely millions of patients
Mounjaro's UK SmPC describes stepups in 2.5 mg increments after at least 4 weeks at a dose
So youre potentially adding a drug that slows gastric emptying to a body that already has a predisposition to gastric dysmotility