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Event Phase 2 Rate (12 mg group) Phase 2 Rate (Placebo) Nausea 45.8% 11.6% Diarrhea 33.3% 9.3% Vomiting 22.2% 2.3% Constipation 16.7% 7.0% Decreased appetite 22.2% 2.3% The nausea incidence at the highest dose a nausea percentage of roughly 46% makes it the single most reported adverse event in retatrutide clinical trials 2026 data
Patients are often asked to participate in supervised programs that include diet, exercise, and behavioral support
Participants in one trial lost around 15% of their body weight over 72 weeks, with many losing more than 20% at a higher dosage
What we really need next are prospective studies or at least carefully designed emulated target trials to validate whether the survival signal persists under more rigorous causal inference frameworks
For more information, please contact Laura Mehegan at [email protected]
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