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This increased energy expenditure contributes to weight loss

Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes

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Estrogen and NGF synergistically protect terminally differentiated, ER-transfected PC12 cells from apoptosis

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Data are still preliminary, and larger trials will be needed to confirm these effects