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The window for market entry remains open partly due to persistent supply constraints among current manufacturers and partly because the addressable patient population continues expanding as clinical evidence mounts for GLP-1 benefits across obesity, diabetes, MASH, cardiovascular disease, and other indications
[11] [12] Prescribers should check the relevant SmPC for hepatic guidance for each agent Use in pregnancy and breastfeeding : DPP-4 inhibitors are not recommended during pregnancy or breastfeeding, as data on safety in these situations are limited
Metabolism 2020;113:154388.ArticlePubMed 73
The field moved from single GLP-1 receptor agonism, to dual GIP/GLP-1 agonism, and then to adding a third receptor glucagon to capture an energy-expenditure lever on top of appetite and glucose control
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