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Our study describes a novel action of GLP-1 signalling in -cells, which stimulates metabolic/bioenergetic reprograming resulting in a high glycolytic/high ATP generating phenotype, as detailed in (Fig

While GLP-1 receptor agonists have a lower risk of hypoglycaemia when used alone (compared to some other diabetes medications), this risk increases significantly when combined with sulfonylureas or insulin

Harris L, Hamilton S, Azevedo LB, Olajide J, De Brn C, Waller G et al (2018) Intermittent fasting interventions for overweight and obesity

The confirmed cancer concern with GLP-1 agonists involves thyroid C-cell tumors, based on rodent studies showing medullary thyroid carcinoma at high drug exposures

The peptide has been administered at doses far exceeding those used therapeutically without significant adverse effects

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