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ICAM-1: intracellular adhesion molecule-1
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This correlates with an increased GST activity in the tissue, which translates in a reduced CSF level of 1-chloro-2,4-dinitrobenzene (CDNB), a prototypic GST substrate used to evaluate in vivo the efficiency of the GSH-dependent enzymatic blood-CSF barrier
No new or unexpected safety signals emerged from the Phase 3 data that had not already been identified in Phase 2
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